Effects of low molecular weight sulfated galactan fragments from botryocladia occidentalis on the pharmacological and enzymatic activity of sPLA2 from Crotalus durissus cascavella
Tipo
Artigo
Data de publicação
2010
Periódico
Protein Journal
Citações (Scopus)
8
Autores
Toyama M.H.
Toyama D.O.
Torres V.M.
Pontes G.C.
Farias W.R.L.
Melo F.R.
Oliveira S.C.B.
Fagundes F.H.R.
Diz Filho E.B.S.
Cavada B.S.
Toyama D.O.
Torres V.M.
Pontes G.C.
Farias W.R.L.
Melo F.R.
Oliveira S.C.B.
Fagundes F.H.R.
Diz Filho E.B.S.
Cavada B.S.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2. © 2010 Springer Science+Business Media, LLC.