Effects of low molecular weight sulfated galactan fragments from botryocladia occidentalis on the pharmacological and enzymatic activity of sPLA2 from Crotalus durissus cascavella
item.page.type
Artigo
Date
2010
item.page.ispartof
Protein Journal
item.page.citationsscopus
8
Authors
Toyama M.H.
Toyama D.O.
Torres V.M.
Pontes G.C.
Farias W.R.L.
Melo F.R.
Oliveira S.C.B.
Fagundes F.H.R.
Diz Filho E.B.S.
Cavada B.S.
Toyama D.O.
Torres V.M.
Pontes G.C.
Farias W.R.L.
Melo F.R.
Oliveira S.C.B.
Fagundes F.H.R.
Diz Filho E.B.S.
Cavada B.S.
publication.page.advisor
Journal Title
Journal ISSN
Volume Title
publication.page.board
publication.page.program
Abstract
Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2. © 2010 Springer Science+Business Media, LLC.