Effects of low molecular weight sulfated galactan fragments from botryocladia occidentalis on the pharmacological and enzymatic activity of sPLA2 from Crotalus durissus cascavella

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dc.contributor.authorToyama M.H.
dc.contributor.authorToyama D.O.
dc.contributor.authorTorres V.M.
dc.contributor.authorPontes G.C.
dc.contributor.authorFarias W.R.L.
dc.contributor.authorMelo F.R.
dc.contributor.authorOliveira S.C.B.
dc.contributor.authorFagundes F.H.R.
dc.contributor.authorDiz Filho E.B.S.
dc.contributor.authorCavada B.S.
dc.date.accessioned2024-03-13T01:32:35Z
dc.date.available2024-03-13T01:32:35Z
dc.date.issued2010
dc.description.abstractLow molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2. © 2010 Springer Science+Business Media, LLC.
dc.description.firstpage567
dc.description.issuenumber8
dc.description.lastpage571
dc.description.volume29
dc.identifier.doi10.1007/s10930-010-9294-9
dc.identifier.issn1875-8355
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37243
dc.relation.ispartofProtein Journal
dc.rightsAcesso Restrito
dc.subject.otherlanguageBotryocladia occidentalis
dc.subject.otherlanguageCrotalus durissus cascavella
dc.subject.otherlanguageEdema
dc.subject.otherlanguageMyonecrosis
dc.subject.otherlanguageSecretory phospholipase A2 (sPLA2)
dc.titleEffects of low molecular weight sulfated galactan fragments from botryocladia occidentalis on the pharmacological and enzymatic activity of sPLA2 from Crotalus durissus cascavella
dc.typeArtigo
local.scopus.citations8
local.scopus.eid2-s2.0-78649908466
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78649908466&origin=inward
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