Avaliação do repertório comportamental TDAH-LIKE de ratos injetados com pilocarpina que desenvolveram Status Epilepticus

Página do item simplificado
dc.contributor.advisorCysneiros, Roberta Monterazzopt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/9822955080635086por
dc.contributor.authorBarbosa, Geraldo Henrique Lemospt_BR
dc.creator.Latteshttp://lattes.cnpq.br/0208087770040481por
dc.date.accessioned2016-03-15T19:39:56Z
dc.date.accessioned2020-03-19T15:19:57Z
dc.date.available2012-11-30pt_BR
dc.date.available2020-03-19T15:19:57Z
dc.date.issued2012-08-16pt_BR
dc.description.abstractEpilepsy is a multifactorial disease, multi-faceted, featuring different variations in severity from person to person, characterized by the emergence of spontaneous seizures due to neuronal hyperactivity. Among the epilepsies, temporal lobe epilepsy (TLE) is a very serious and common, comprising about 40% of all cases, often refractory to medication with a substantial impact on cognitive processes and behavior of the affected person. The ELT is characterized by the presence of complex partial seizures with onset in limbic structures, partially attributed to more frequent primary neuropathology, hippocampal sclerosis. This crisis can cause behavioral and cognitive impairments associated with psychiatric disorders, which Disorder Attention Deficit Hyperactivity Disorder (ADHD). In order to evaluate the locomotor activity and exploration in young rats subjected to status epilepticus. Male Wistar rats aged 25 days postnatal, received intraperitoneal injection of pilocarpine (350mg/kg). Control animals received saline. The model induced by pilocarpine was used in this study, given that their histological, biochemical, electrophysiological and behavioral reliably reproduce those found in human TLE. After induction by pilocarpine SE animals underwent behavioral tests that began five days after SE and were completed in 15 days. They were: the open field and elevated plus maze. The present study showed evidence that young animals subjected to status epilepticus exhibit moderate hyperactivity with increased emotionality in a threatening context. Hyperactivity was observed over time, when the animals were reintroduced to an environment with neutral context (open field) or immediately when exposed to a threatening environment (LCE). The results of this study argue for the simultaneous presence of ADHD in the model of TLE. Evidence shows that behavioral changes are manifested early, even before the installation of behavioral seizures. In this respect, it opens a window of opportunity to get early interventions that may minimize the deleterious consequences of seizures.eng
dc.description.sponsorshipFundo Mackenzie de Pesquisapt_BR
dc.formatapplication/pdfpor
dc.identifier.citationBARBOSA, Geraldo Henrique Lemos. Avaliação do repertório comportamental TDAH-LIKE de ratos injetados com pilocarpina que desenvolveram Status Epilepticus. 2012. 49 f. Dissertação (Mestrado em Psicologia) - Universidade Presbiteriana Mackenzie, São Paulo, 2012.por
dc.identifier.urihttp://dspace.mackenzie.br/handle/10899/22509
dc.languageporpor
dc.publisherUniversidade Presbiteriana Mackenziepor
dc.rightsAcesso Abertopor
dc.subjectEpilepsia do Lobo Temporalpor
dc.subjectStatus Epilepticuspor
dc.subjectTranstorno de Déficit de Atenção e Hiperatividadepor
dc.subjectrepertório comportamentalpor
dc.subjectTemporal Lobe Epilepsyeng
dc.subjectStatus Epilepticuseng
dc.subjectattention deficit hyperactivity disordereng
dc.subjectbehavioral repertoireeng
dc.subject.cnpqCNPQ::CIENCIAS HUMANAS::PSICOLOGIApor
dc.thumbnail.urlhttp://tede.mackenzie.br/jspui/retrieve/3675/Geraldo%20Henrique%20Lemos%20Barbosa.pdf.jpg*
dc.titleAvaliação do repertório comportamental TDAH-LIKE de ratos injetados com pilocarpina que desenvolveram Status Epilepticuspor
dc.typeDissertaçãopor
local.contributor.board1Ribeiro, Miriam Oliveirapt_BR
local.contributor.board1Latteshttp://lattes.cnpq.br/7069953370349465por
local.contributor.board2Scorza, Fúlvio Alexandrept_BR
local.contributor.board2Latteshttp://lattes.cnpq.br/3665794780601169por
local.publisher.countryBRpor
local.publisher.departmentPsicologiapor
local.publisher.initialsUPMpor
local.publisher.programDistúrbios do Desenvolvimentopor
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Geraldo Henrique Lemos Barbosa.pdf
Tamanho:
727.33 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
Distúrbios do Desenvolvimento - Dissertações - CCBS Higienópolis