Avaliação do repertório comportamental TDAH-LIKE de ratos injetados com pilocarpina que desenvolveram Status Epilepticus
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Tipo
Dissertação
Data de publicação
2012-08-16
Periódico
Citações (Scopus)
Autores
Barbosa, Geraldo Henrique Lemos
Orientador
Cysneiros, Roberta Monterazzo
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Ribeiro, Miriam Oliveira
Scorza, Fúlvio Alexandre
Scorza, Fúlvio Alexandre
Programa
Distúrbios do Desenvolvimento
Resumo
Epilepsy is a multifactorial disease, multi-faceted, featuring different variations in severity from person to person, characterized by the emergence of spontaneous seizures due to neuronal hyperactivity. Among the epilepsies, temporal lobe epilepsy (TLE) is a very serious and common, comprising about 40% of all cases, often refractory to medication with a substantial impact on cognitive processes and behavior of the affected person. The ELT is characterized by the presence of complex partial seizures with onset in limbic structures, partially attributed to more frequent primary neuropathology, hippocampal sclerosis. This crisis can cause behavioral and cognitive impairments associated with psychiatric disorders, which Disorder Attention Deficit Hyperactivity Disorder (ADHD). In order to evaluate the locomotor activity and exploration in young rats subjected to status epilepticus. Male Wistar rats aged 25 days postnatal, received intraperitoneal injection of pilocarpine (350mg/kg). Control animals received saline. The model induced by pilocarpine was used in this study, given that their histological, biochemical, electrophysiological and behavioral reliably reproduce those found in human TLE. After induction by pilocarpine SE animals underwent behavioral tests that began five days after SE and were completed in 15 days. They were: the open field and elevated plus maze. The present study showed evidence that young animals subjected to status epilepticus exhibit moderate hyperactivity with increased emotionality in a threatening context. Hyperactivity was observed over time, when the animals were reintroduced to an environment with neutral context (open field) or immediately when exposed to a threatening environment (LCE). The results of this study argue for the simultaneous presence of ADHD in the model of TLE. Evidence shows that behavioral changes are manifested early, even before the installation of behavioral seizures. In this respect, it opens a window of opportunity to get early interventions that may minimize the deleterious consequences of seizures.
Descrição
Palavras-chave
Epilepsia do Lobo Temporal , Status Epilepticus , Transtorno de Déficit de Atenção e Hiperatividade , repertório comportamental , Temporal Lobe Epilepsy , Status Epilepticus , attention deficit hyperactivity disorder , behavioral repertoire
Assuntos Scopus
Citação
BARBOSA, Geraldo Henrique Lemos. Avaliação do repertório comportamental TDAH-LIKE de ratos injetados com pilocarpina que desenvolveram Status Epilepticus. 2012. 49 f. Dissertação (Mestrado em Psicologia) - Universidade Presbiteriana Mackenzie, São Paulo, 2012.