Antifungal piperolides from Piper malacophyllum (Prels) C. DC.
Tipo
Artigo
Data de publicação
2005
Periódico
Journal of the Brazilian Chemical Society
Citações (Scopus)
30
Autores
Lago J.H.G.
Tanizaki T.M.
Young M.C.M.
Guimaraes E.F.
Kato M.J.
Tanizaki T.M.
Young M.C.M.
Guimaraes E.F.
Kato M.J.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
Bioactivity-guided fractionation of the CH2Cl2 extract from leaves of Piper malacophyllum using bioautography assay against fungi, led to the isolation of two known bioactive piperolides: 4,6-dimethoxy-5-E-phenylbutenolide (1) and 4,6-dimethoxy-5-Z-phenylbutenolide (2). IR, MS and NMR spectroscopic data were used for the identification of these compounds including comparison with previously reported data. The E configuration is associated to higher activity for compound 1, since the minimum amount required for the growth inhibition of Cladosporium cladosporioides and C. sphaerospermum were 1.0/1.0 μg (1) and 5.0/10.0 μg (2), respectively. ©2005 Sociedade Brasileira de Química.