Antifungal piperolides from Piper malacophyllum (Prels) C. DC.
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Artigo
Date
2005
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Journal of the Brazilian Chemical Society
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30
Authors
Lago J.H.G.
Tanizaki T.M.
Young M.C.M.
Guimaraes E.F.
Kato M.J.
Tanizaki T.M.
Young M.C.M.
Guimaraes E.F.
Kato M.J.
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Volume Title
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Abstract
Bioactivity-guided fractionation of the CH2Cl2 extract from leaves of Piper malacophyllum using bioautography assay against fungi, led to the isolation of two known bioactive piperolides: 4,6-dimethoxy-5-E-phenylbutenolide (1) and 4,6-dimethoxy-5-Z-phenylbutenolide (2). IR, MS and NMR spectroscopic data were used for the identification of these compounds including comparison with previously reported data. The E configuration is associated to higher activity for compound 1, since the minimum amount required for the growth inhibition of Cladosporium cladosporioides and C. sphaerospermum were 1.0/1.0 μg (1) and 5.0/10.0 μg (2), respectively. ©2005 Sociedade Brasileira de Química.