Antifungal piperolides from Piper malacophyllum (Prels) C. DC.

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dc.contributor.authorLago J.H.G.
dc.contributor.authorTanizaki T.M.
dc.contributor.authorYoung M.C.M.
dc.contributor.authorGuimaraes E.F.
dc.contributor.authorKato M.J.
dc.date.accessioned2024-03-13T01:44:32Z
dc.date.available2024-03-13T01:44:32Z
dc.date.issued2005
dc.description.abstractBioactivity-guided fractionation of the CH2Cl2 extract from leaves of Piper malacophyllum using bioautography assay against fungi, led to the isolation of two known bioactive piperolides: 4,6-dimethoxy-5-E-phenylbutenolide (1) and 4,6-dimethoxy-5-Z-phenylbutenolide (2). IR, MS and NMR spectroscopic data were used for the identification of these compounds including comparison with previously reported data. The E configuration is associated to higher activity for compound 1, since the minimum amount required for the growth inhibition of Cladosporium cladosporioides and C. sphaerospermum were 1.0/1.0 μg (1) and 5.0/10.0 μg (2), respectively. ©2005 Sociedade Brasileira de Química.
dc.description.firstpage153
dc.description.issuenumber2
dc.description.lastpage156
dc.description.volume16
dc.identifier.doi10.1590/S0103-50532005000200005
dc.identifier.issn0103-5053
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37902
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.rightsAcesso Aberto
dc.subject.otherlanguageAntifungal activity
dc.subject.otherlanguagePiper malacophyllum
dc.subject.otherlanguagePiperolides
dc.titleAntifungal piperolides from Piper malacophyllum (Prels) C. DC.
dc.typeArtigo
local.scopus.citations30
local.scopus.eid2-s2.0-20444391667
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=20444391667&origin=inward
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