Naturally acquired antibodies to tetanus toxin in humans and animals from the Galapagos Islands
Tipo
Artigo
Data de publicação
1983
Periódico
Journal of Infectious Diseases
Citações (Scopus)
24
Autores
Veronesi R.
Bizzini B.
Focaccia R.
Coscina A.L.
Mazza C.C.
Focaccia M.T.
Carraro F.
Honningman M.N.
Bizzini B.
Focaccia R.
Coscina A.L.
Mazza C.C.
Focaccia M.T.
Carraro F.
Honningman M.N.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
A serologic survey using a highly sensitive enzyme-linked immunosorbent assay confirmed the anticipated finding of naturally acquired antibodies to tetanus toxin both in humans and animals on the Galapagos Islands. In 57 inhabitants (mean age, 31.3 years) who had not been vaccinated against tetanus, antibody to tetanus toxin was detected in the blood by varying titers (geometric mean [reciprocal] titer [GMT], 0.015 international units [IU]/ml). In one individual the titer of antibody was > 12.5 IU/ml. Two individuals who had never been vaccinated against tetanus but who had reported having had clinical tetanus had titers of antibody to tetanus toxin of 0.02 IU/ml and 0.3 IU/ml, respectively. All nine of the animals studied showed antibody to tetanus toxin (GMT, 0.028 IU/ml).