Evaluation of antifungal and DNA-damaging activities of alkaloids from branches of Porcelia macrocarpa
Tipo
Artigo
Data de publicação
2007
Periódico
Planta Medica
Citações (Scopus)
38
Autores
Lago J.H.G.
Chaves M.H.
Ayres M.C.C.
Agripino D.G.
Young M.C.M.
Chaves M.H.
Ayres M.C.C.
Agripino D.G.
Young M.C.M.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
Bioactivity-guided fractionation of the alkaloidal fractions of the CH 2Cl2 extract from branches of Porcelia macrocarpa using mutant yeast strains of Saccharomyces cerevisiae and fungi Cladosporium cladosporioides and C. sphaerospermum led to the isolation of bioactive alkaloids: two tetrahydrobenzylisoquinolines (1 and 2), two aporphines (3 and 4), one proaporphine (5), one oxoaporphine (6), four azantraquinones (7-10) and four azafluorenones (11-14). The alkaloids cleistopholine (7) and 6-methoxycleistopholine (8) showed the highest fungitoxic activity while the mixture of 6- and 7-methoxyonychine (12 + 13) and 6,7-dimethoxyonychine (14) showed a weak DNA-damaging potential. © Georg Thieme Verlag KG Stuttgart.