Evaluation of antifungal and DNA-damaging activities of alkaloids from branches of Porcelia macrocarpa

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dc.contributor.authorLago J.H.G.
dc.contributor.authorChaves M.H.
dc.contributor.authorAyres M.C.C.
dc.contributor.authorAgripino D.G.
dc.contributor.authorYoung M.C.M.
dc.date.accessioned2024-03-13T01:40:03Z
dc.date.available2024-03-13T01:40:03Z
dc.date.issued2007
dc.description.abstractBioactivity-guided fractionation of the alkaloidal fractions of the CH 2Cl2 extract from branches of Porcelia macrocarpa using mutant yeast strains of Saccharomyces cerevisiae and fungi Cladosporium cladosporioides and C. sphaerospermum led to the isolation of bioactive alkaloids: two tetrahydrobenzylisoquinolines (1 and 2), two aporphines (3 and 4), one proaporphine (5), one oxoaporphine (6), four azantraquinones (7-10) and four azafluorenones (11-14). The alkaloids cleistopholine (7) and 6-methoxycleistopholine (8) showed the highest fungitoxic activity while the mixture of 6- and 7-methoxyonychine (12 + 13) and 6,7-dimethoxyonychine (14) showed a weak DNA-damaging potential. © Georg Thieme Verlag KG Stuttgart.
dc.description.firstpage292
dc.description.issuenumber3
dc.description.lastpage295
dc.description.volume73
dc.identifier.doi10.1055/s-2007-967108
dc.identifier.issn0032-0943
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37658
dc.relation.ispartofPlanta Medica
dc.rightsAcesso Restrito
dc.titleEvaluation of antifungal and DNA-damaging activities of alkaloids from branches of Porcelia macrocarpa
dc.typeArtigo
local.scopus.citations38
local.scopus.eid2-s2.0-34250340130
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34250340130&origin=inward
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