Systemic lupus erythematosus activity and serum bilirubins
Tipo
Artigo
Data de publicação
2013
Periódico
Acta Reumatologica Portuguesa
Citações (Scopus)
15
Autores
dos Santos B.H.
Almeida C.M.R.
Skare T.L.
Almeida C.M.R.
Skare T.L.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
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Resumo
Background: Serum bilirubins play an important role in controlling oxidative stress; there is increased oxidative stress during activity of rheumatic diseases such as systemic lupus erythematosus (SLE). Objective: To study bilirubin levels in SLE (Systemic Lupus Erythematosus) patients and relate them to disease activity. Methods: We analyzed levels of total bilirubins (TB), direct bilirubins (DB) and indirect bilirubins (IB), sedimentation rate (ESR) and C reactive protein (CRP) in 143 SLE patients. Data were collected on the clinical and autoantibody profiles and patients underwent measurement of SLEDAI and SLICC. Results: Correlation of indirect bilirubin values with SLEDAI was negative (p=0.02; Spearman rho=-0.18). Comparing the levels of IB according to the clinical activity profile we observed associations with increase of anti DNA titer (p=0.027) and with decrease in complement levels (p=0.017). ESR correlated negatively with IB levels (p=0.01) but CRP did not (p=0.15). In a multiple linear regression analysis only the increase in ESR titer remained significant. SLICC values were not correlated with TB (p=0.30), DB (p=0.12) or IB (p=0.31). Conclusions: We conclude that IB levels in SLE correlate negatively with disease activity. IB levels are lower in patients with higher ESR.
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Assuntos Scopus
Adolescent , Adult , Aged , Bilirubin , Female , Humans , Lupus Erythematosus, Systemic , Male , Middle Aged , Oxidative Stress , Young Adult