Systemic lupus erythematosus activity and serum bilirubins

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dc.contributor.authordos Santos B.H.
dc.contributor.authorAlmeida C.M.R.
dc.contributor.authorSkare T.L.
dc.date.accessioned2024-03-13T01:03:10Z
dc.date.available2024-03-13T01:03:10Z
dc.date.issued2013
dc.description.abstractBackground: Serum bilirubins play an important role in controlling oxidative stress; there is increased oxidative stress during activity of rheumatic diseases such as systemic lupus erythematosus (SLE). Objective: To study bilirubin levels in SLE (Systemic Lupus Erythematosus) patients and relate them to disease activity. Methods: We analyzed levels of total bilirubins (TB), direct bilirubins (DB) and indirect bilirubins (IB), sedimentation rate (ESR) and C reactive protein (CRP) in 143 SLE patients. Data were collected on the clinical and autoantibody profiles and patients underwent measurement of SLEDAI and SLICC. Results: Correlation of indirect bilirubin values with SLEDAI was negative (p=0.02; Spearman rho=-0.18). Comparing the levels of IB according to the clinical activity profile we observed associations with increase of anti DNA titer (p=0.027) and with decrease in complement levels (p=0.017). ESR correlated negatively with IB levels (p=0.01) but CRP did not (p=0.15). In a multiple linear regression analysis only the increase in ESR titer remained significant. SLICC values were not correlated with TB (p=0.30), DB (p=0.12) or IB (p=0.31). Conclusions: We conclude that IB levels in SLE correlate negatively with disease activity. IB levels are lower in patients with higher ESR.
dc.description.firstpage242
dc.description.issuenumber4
dc.description.lastpage246
dc.description.volume38
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36532
dc.relation.ispartofActa Reumatologica Portuguesa
dc.rightsAcesso Restrito
dc.subject.otherlanguageBilirubins
dc.subject.otherlanguageOxidative stress
dc.subject.otherlanguageSystemic lupus erythematosus
dc.titleSystemic lupus erythematosus activity and serum bilirubins
dc.typeArtigo
local.scopus.citations15
local.scopus.eid2-s2.0-84893501646
local.scopus.subjectAdolescent
local.scopus.subjectAdult
local.scopus.subjectAged
local.scopus.subjectBilirubin
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectLupus Erythematosus, Systemic
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectOxidative Stress
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84893501646&origin=inward
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