Hashimoto thyroiditis may be associated with a subset of patients with systemic sclerosis with pulmonary hypertension

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Revista Brasileira de Reumatologia
Citações (Scopus)
Costa C.C.B.
Medeiros M.
Watanabe K.
Martin P.
Skare T.L.
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© 2014 Elsevier Editora Ltda.Introduction: Recent studies show an association between autoimmune thyroiditis and sys-temic sclerosis (SSc) and suggest that this condition may interfere with the ES phenotype. However these studies evaluate the autoimmune thyroiditis as a whole and none of themspecifically addresses Hashimoto's thyroiditis (HT) in SSc. Objective: To investigate the presence of HT in SSc patients and its possible association withdisease manifestations. Methods: Clinical manifestations of hypothyroidism, TSH and anti-thyroid auto antibodies(anti-TPO. anti TBG and TRAb) were studied in 56 patients with SSc. SSc patients with HTwere compared with SSc patients without thyroiditis. Results: HT was observed in 19.64% of patients with SSc. No association was observedbetween HT and the different forms of disease or profile of autoantibodies. Likewise, therewas no difference between the mean modified Rodnan score and presence of Raynaud'sphenomenon, scars, digital necrosis, myositis, arthritis, sicca symptoms, esophageal dys-motility and scleroderma renal crisis when the groups were compared. On the other hand, patients with HT had higher frequency of pulmonary hypertension in relation to patientswithout HT (66.6% vs 22.5%, p = 0.016).Conclusions: In the studied sample patients with ES and HT had higher prevalence of pul-monary hypertension. Long-term follow-up studies with a larger number of TH and SScpatients are needed to confirm these data.
Assuntos Scopus
Adult , Aged , Aged, 80 and over , Cross-Sectional Studies , Female , Hashimoto Disease , Humans , Hypertension, Pulmonary , Male , Middle Aged , Scleroderma, Systemic , Young Adult
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