Hashimoto thyroiditis may be associated with a subset of patients with systemic sclerosis with pulmonary hypertension

dc.contributor.authorCosta C.C.B.
dc.contributor.authorMedeiros M.
dc.contributor.authorWatanabe K.
dc.contributor.authorMartin P.
dc.contributor.authorSkare T.L.
dc.date.accessioned2024-03-13T01:01:10Z
dc.date.available2024-03-13T01:01:10Z
dc.date.issued2014
dc.description.abstract© 2014 Elsevier Editora Ltda.Introduction: Recent studies show an association between autoimmune thyroiditis and sys-temic sclerosis (SSc) and suggest that this condition may interfere with the ES phenotype. However these studies evaluate the autoimmune thyroiditis as a whole and none of themspecifically addresses Hashimoto's thyroiditis (HT) in SSc. Objective: To investigate the presence of HT in SSc patients and its possible association withdisease manifestations. Methods: Clinical manifestations of hypothyroidism, TSH and anti-thyroid auto antibodies(anti-TPO. anti TBG and TRAb) were studied in 56 patients with SSc. SSc patients with HTwere compared with SSc patients without thyroiditis. Results: HT was observed in 19.64% of patients with SSc. No association was observedbetween HT and the different forms of disease or profile of autoantibodies. Likewise, therewas no difference between the mean modified Rodnan score and presence of Raynaud'sphenomenon, scars, digital necrosis, myositis, arthritis, sicca symptoms, esophageal dys-motility and scleroderma renal crisis when the groups were compared. On the other hand, patients with HT had higher frequency of pulmonary hypertension in relation to patientswithout HT (66.6% vs 22.5%, p = 0.016).Conclusions: In the studied sample patients with ES and HT had higher prevalence of pul-monary hypertension. Long-term follow-up studies with a larger number of TH and SScpatients are needed to confirm these data.
dc.description.firstpage366
dc.description.issuenumber5
dc.description.lastpage370
dc.description.volume54
dc.identifier.doi10.1016/j.rbre.2014.04.001
dc.identifier.issn1809-4570
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36420
dc.relation.ispartofRevista Brasileira de Reumatologia
dc.rightsAcesso Aberto
dc.subject.otherlanguageHashimoto thyroiditis
dc.subject.otherlanguagePulmonary hypertension
dc.subject.otherlanguageScleroderma
dc.subject.otherlanguageSystemic sclerosis
dc.titleHashimoto thyroiditis may be associated with a subset of patients with systemic sclerosis with pulmonary hypertension
dc.typeArtigo
local.scopus.citations8
local.scopus.eid2-s2.0-85016497825
local.scopus.subjectAdult
local.scopus.subjectAged
local.scopus.subjectAged, 80 and over
local.scopus.subjectCross-Sectional Studies
local.scopus.subjectFemale
local.scopus.subjectHashimoto Disease
local.scopus.subjectHumans
local.scopus.subjectHypertension, Pulmonary
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectScleroderma, Systemic
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85016497825&origin=inward
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