Efeito do polimorfismo Thr92Ala da enzima desiodase tipo 2 no comportamento adaptativo de indivíduos com Transtorno do Espectro Autista

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dc.contributor.advisorRibeiro, Miriam Oliveira
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7069953370349465por
dc.contributor.authorMarcondes, Alyna Araújo e
dc.creator.Latteshttp://lattes.cnpq.br/5763681422634997por
dc.date.accessioned2019-06-27T15:23:37Z
dc.date.accessioned2020-03-19T15:20:43Z
dc.date.available2020-03-19T15:20:43Z
dc.date.issued2018-12-12
dc.description.abstractThr92Ala D2 it’s the polymorphism of a thyroid hormone enzyme responsible to convert T4 in its active form, T3. This polymorphism has been related to Schizophrenia, Depression and Alzheimer’s disease, and its been shown that in the presence of both polymorphic alleles there’s a difference in the expression of genes relates to neurodegenerative process and oxidative stress in Central Nervous System (CNS). Studies with Autism Spectrum Disorder (ASD) patients has demonstrated that in this group, cells are more likely to present oxidative stress condition. The aim of this study was to evaluate whether ASD patients expressing Thr92Ala-D2 polymorphism would have poorer results at cognitive and behavioral tests when compared with patients without the polymorphism. Were assessed 132 ASD patients and the results of Autism Behavior Checklist (ABC), Vineland Scale of Adaptative Behavior, IQ and Autism Treatment Evaluation Checklist (ATEC). The analyses showed that patients expressing the polymorphism had better performances in Communication, Receptive Communication, Daily Living and Selfcare, although patients with wild genotyping and more critical ABC results had significative improvement of their social skills after interventions. Therefore, the existence of polymorphism improves adaptative performance in ASD patients, however the polymorphism seems to impair patient’s response to therapies. More researches are necessary in order to improve the comprehension of enzyme’s role and mechanisms underlying polymorphism’s CNS fingerprint.eng
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dc.identifier.citationMARCONDES, Alyna Araújo e. Efeito do polimorfismo Thr92Ala da enzima desiodase tipo 2 no comportamento adaptativo de indivíduos com Transtorno do Espectro Autista. 2018. 57 f. Dissertação (Distúrbios do Desenvolvimento) - Universidade Presbiteriana Mackenzie, São Paulo, 2018.por
dc.identifier.urihttp://dspace.mackenzie.br/handle/10899/22763
dc.keywordsThr92Ala-D2 polymorphismeng
dc.keywordsASDeng
dc.keywordsadaptive behavioreng
dc.languageporpor
dc.publisherUniversidade Presbiteriana Mackenziepor
dc.rightsAcesso Abertopor
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectpolimorfismo Thr92Ala D2opor
dc.subjectTEApor
dc.subjectcomportamento adaptativopor
dc.subject.cnpqCNPQ::CIENCIAS HUMANAS::PSICOLOGIApor
dc.subject.cnpqCNPQ::CIENCIAS HUMANAS::EDUCACAOpor
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpor
dc.thumbnail.urlhttp://tede.mackenzie.br/jspui/retrieve/19144/Alyna%20Marcondes.pdf.jpg*
dc.titleEfeito do polimorfismo Thr92Ala da enzima desiodase tipo 2 no comportamento adaptativo de indivíduos com Transtorno do Espectro Autistapor
dc.typeDissertaçãopor
local.contributor.board1Rocha, Marina Monzani da
local.contributor.board1Latteshttp://lattes.cnpq.br/6765747992813196por
local.contributor.board2Lowenthal, Rosane
local.contributor.board2Latteshttp://lattes.cnpq.br/3764252492071682por
local.publisher.countryBrasilpor
local.publisher.departmentCentro de Ciências Biológicas e da Saúde (CCBS)por
local.publisher.initialsUPMpor
local.publisher.programDistúrbios do Desenvolvimentopor
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