Social play impairment following status epilepticus during early development

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dc.contributor.authorCastelhano A.S.S.
dc.contributor.authorScorza F.A.
dc.contributor.authorTeixeira M.C.T.V.
dc.contributor.authorArida R.M.
dc.contributor.authorCavalheiro E.A.
dc.contributor.authorCysneiros R.M.
dc.date.accessioned2024-03-13T01:30:51Z
dc.date.available2024-03-13T01:30:51Z
dc.date.issued2010
dc.description.abstractNeonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the "intruder-resident" paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span. © 2010 Springer-Verlag.
dc.description.firstpage1155
dc.description.issuenumber10
dc.description.lastpage1160
dc.description.volume117
dc.identifier.doi10.1007/s00702-010-0460-1
dc.identifier.issn0300-9564
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37146
dc.relation.ispartofJournal of Neural Transmission
dc.rightsAcesso Restrito
dc.subject.otherlanguageGender
dc.subject.otherlanguageNeonatal
dc.subject.otherlanguageSocial interaction
dc.subject.otherlanguageStatus epilepticus
dc.titleSocial play impairment following status epilepticus during early development
dc.typeArtigo
local.scopus.citations13
local.scopus.eid2-s2.0-78651236574
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78651236574&origin=inward
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