Social play impairment following status epilepticus during early development
Tipo
Artigo
Data de publicação
2010
Periódico
Journal of Neural Transmission
Citações (Scopus)
13
Autores
Castelhano A.S.S.
Scorza F.A.
Teixeira M.C.T.V.
Arida R.M.
Cavalheiro E.A.
Cysneiros R.M.
Scorza F.A.
Teixeira M.C.T.V.
Arida R.M.
Cavalheiro E.A.
Cysneiros R.M.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
Neonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the "intruder-resident" paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span. © 2010 Springer-Verlag.