Monoamine neurotransmitters and mood swings: A dynamical systems approach

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dc.contributor.authorLoula R.
dc.contributor.authorMonteiro L.H.A.
dc.date.accessioned2024-03-12T19:17:44Z
dc.date.available2024-03-12T19:17:44Z
dc.date.issued2022
dc.description.abstract© 2022 American Institute of Mathematical Sciences. All rights reserved.Serotonin, dopamine and norepinephrine are monoamine neurotransmitters that modulate our mood state. Hence, imbalances in the levels of these neurotransmitters have been linked to the incidence of several psychiatric disorders. Here, a mathematical model written in terms of ordinary differential equations is proposed to represent the interaction of these three neurotransmitters. It is analytically and numerically shown that this model can experience a Hopf bifurcation. Thus, by varying a parameter value, the neurotransmitter levels can change from a steady state to an oscillatory behavior, which may be at least a partial explanation of the mood swings observed in depressed people.
dc.description.firstpage4075
dc.description.issuenumber4
dc.description.lastpage4083
dc.description.volume19
dc.identifier.doi10.3934/mbe.2022187
dc.identifier.issn1551-0018
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34513
dc.relation.ispartofMathematical Biosciences and Engineering
dc.rightsAcesso Aberto
dc.subject.otherlanguageDopamine
dc.subject.otherlanguageDynamical system
dc.subject.otherlanguageHopf bifurcation
dc.subject.otherlanguageMood instability
dc.subject.otherlanguageNorepinephrine
dc.subject.otherlanguageSerotonin
dc.titleMonoamine neurotransmitters and mood swings: A dynamical systems approach
dc.typeArtigo
local.scopus.citations8
local.scopus.eid2-s2.0-85124796131
local.scopus.subjectDopamine
local.scopus.subjectDynamical systems approach
local.scopus.subjectMonoamine neurotransmitters
local.scopus.subjectMood instability
local.scopus.subjectNeurotransmitter level
local.scopus.subjectOscillatory behaviors
local.scopus.subjectPsychiatric disorders
local.scopus.subjectSerotonin
local.scopus.subjectSteady state
local.scopus.subjectDopamine
local.scopus.subjectHumans
local.scopus.subjectModels, Theoretical
local.scopus.subjectNeurotransmitter Agents
local.scopus.subjectSerotonin
local.scopus.subjectSystems Analysis
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85124796131&origin=inward
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