Monoamine neurotransmitters and mood swings: A dynamical systems approach
Tipo
Artigo
Data de publicação
2022
Periódico
Mathematical Biosciences and Engineering
Citações (Scopus)
8
Autores
Loula R.
Monteiro L.H.A.
Monteiro L.H.A.
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© 2022 American Institute of Mathematical Sciences. All rights reserved.Serotonin, dopamine and norepinephrine are monoamine neurotransmitters that modulate our mood state. Hence, imbalances in the levels of these neurotransmitters have been linked to the incidence of several psychiatric disorders. Here, a mathematical model written in terms of ordinary differential equations is proposed to represent the interaction of these three neurotransmitters. It is analytically and numerically shown that this model can experience a Hopf bifurcation. Thus, by varying a parameter value, the neurotransmitter levels can change from a steady state to an oscillatory behavior, which may be at least a partial explanation of the mood swings observed in depressed people.
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Assuntos Scopus
Dopamine , Dynamical systems approach , Monoamine neurotransmitters , Mood instability , Neurotransmitter level , Oscillatory behaviors , Psychiatric disorders , Serotonin , Steady state , Dopamine , Humans , Models, Theoretical , Neurotransmitter Agents , Serotonin , Systems Analysis