Chemical constituents from Piper marginatum Jacq. (Piperaceae)-antifungal activities and kinetic resolution of (RS)-marginatumol by Candida antarctica lipase (Novozym 435)

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dc.contributor.authorReigada J.B.
dc.contributor.authorTcacenco Celize.M.
dc.contributor.authorAndrade L.H.
dc.contributor.authorKato M.J.
dc.contributor.authorPorto A.L.M.
dc.contributor.authorLago J.H.G.
dc.date.accessioned2024-03-13T01:39:53Z
dc.date.available2024-03-13T01:39:53Z
dc.date.issued2007
dc.description.abstractThe leaves of Piper marginatum contain the antifungal compounds 3,4-methylenedioxypropiophenone 1, 2-methoxy-4,5-methylenedioxypropiophenone 2, 1-(3,4-methylenedioxyphenyl)propan-1-ol 3 (marginatumol), 5,4′-dihydroxy-7-methoxyflavanone 4 and 5,7-dihydroxy-4′-methoxyflavanone 5. The absolute configuration of natural marginatumol was determined as (+)-(R)-3 (ee 48%) by comparison of its optical properties with the chiral forms obtained by kinetic resolution of racemic 3 using Candida antarctica lipase (Novozym 435). © 2007 Elsevier Ltd. All rights reserved.
dc.description.firstpage1054
dc.description.issuenumber9
dc.description.lastpage1058
dc.description.volume18
dc.identifier.doi10.1016/j.tetasy.2007.05.006
dc.identifier.issn0957-4166
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37649
dc.relation.ispartofTetrahedron Asymmetry
dc.rightsAcesso Restrito
dc.titleChemical constituents from Piper marginatum Jacq. (Piperaceae)-antifungal activities and kinetic resolution of (RS)-marginatumol by Candida antarctica lipase (Novozym 435)
dc.typeArtigo
local.scopus.citations30
local.scopus.eid2-s2.0-34249864780
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34249864780&origin=inward
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