Chemical constituents from Piper marginatum Jacq. (Piperaceae)-antifungal activities and kinetic resolution of (RS)-marginatumol by Candida antarctica lipase (Novozym 435)
Tipo
Artigo
Data de publicação
2007
Periódico
Tetrahedron Asymmetry
Citações (Scopus)
30
Autores
Reigada J.B.
Tcacenco Celize.M.
Andrade L.H.
Kato M.J.
Porto A.L.M.
Lago J.H.G.
Tcacenco Celize.M.
Andrade L.H.
Kato M.J.
Porto A.L.M.
Lago J.H.G.
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Resumo
The leaves of Piper marginatum contain the antifungal compounds 3,4-methylenedioxypropiophenone 1, 2-methoxy-4,5-methylenedioxypropiophenone 2, 1-(3,4-methylenedioxyphenyl)propan-1-ol 3 (marginatumol), 5,4′-dihydroxy-7-methoxyflavanone 4 and 5,7-dihydroxy-4′-methoxyflavanone 5. The absolute configuration of natural marginatumol was determined as (+)-(R)-3 (ee 48%) by comparison of its optical properties with the chiral forms obtained by kinetic resolution of racemic 3 using Candida antarctica lipase (Novozym 435). © 2007 Elsevier Ltd. All rights reserved.