Fluoxetine alters rat's milk properties causing impact on offspring's development

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dc.contributor.authorAbreu G.R.
dc.contributor.authorZaccarelli-Magalhaes J.
dc.contributor.authorFeba L.S.
dc.contributor.authorPenna E.Y.
dc.contributor.authorSilva J.P.
dc.contributor.authorTeixeira M.V.
dc.contributor.authorManes M.
dc.contributor.authorVergara G.A.
dc.contributor.authorRodrigues L.M.A.
dc.contributor.authorFukushima A.R.
dc.contributor.authorRicci E.L.
dc.contributor.authorSpinosa H.S.
dc.date.accessioned2024-03-12T19:07:03Z
dc.date.available2024-03-12T19:07:03Z
dc.date.issued2024
dc.description.abstract© 2024 Elsevier Inc.Fluoxetine is an antidepressant used to treat several conditions including postpartum depression. This disease causes cognitive, emotional, behavioral and physical changes, negatively affecting the mother, child and family life. However, fluoxetine is excreted in breast milk, causing short and long-term effects on children who were exposed to the drug during lactation, so studies that seek to uncover the consequences of these effects are needed. Thus, the aim of this study was to evaluate the effects of fluoxetine on the nutritional characteristics of milk and on growth and neurobehavioral development of the offspring on a rat model. Lactating rats were divided into 4 groups: control group and three experimental groups, which were treated with different doses of fluoxetine (1, 10 and 20 mg/kg) during the lactation. Dams body weight and milk properties were measured, as well as offspring's growth and physical and neurobehavioral development. Results showed that the use of fluoxetine during lactation decreased dam's body weight and alters milk's properties, leading to a decrease in offspring's growth until adulthood. Therefore, the use of fluoxetine during lactation needs to be cautiously evaluated, with the benefits to the mothers and the associated risk to the offspring carefully balance.
dc.description.volume483
dc.identifier.doi10.1016/j.taap.2024.116805
dc.identifier.issn1096-0333
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/33945
dc.relation.ispartofToxicology and Applied Pharmacology
dc.rightsAcesso Restrito
dc.subject.otherlanguageAntidepressive
dc.subject.otherlanguageDevelopmental toxicity
dc.subject.otherlanguageLactation
dc.subject.otherlanguageNeurobehavior
dc.subject.otherlanguagePeripartum depression
dc.titleFluoxetine alters rat's milk properties causing impact on offspring's development
dc.typeArtigo
local.scopus.citations1
local.scopus.eid2-s2.0-85182388182
local.scopus.subjectAdult
local.scopus.subjectAnimals
local.scopus.subjectAntidepressive Agents
local.scopus.subjectBody Weight
local.scopus.subjectChild
local.scopus.subjectFemale
local.scopus.subjectFluoxetine
local.scopus.subjectHumans
local.scopus.subjectLactation
local.scopus.subjectMilk, Human
local.scopus.subjectRats
local.scopus.updated2025-04-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85182388182&origin=inward
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