Fluoxetine alters rat's milk properties causing impact on offspring's development

Abreu G.R.; Zaccarelli-Magalhaes J.; Feba L.S.; Penna E.Y.; Silva J.P.; Teixeira M.V.; Manes M.; Vergara G.A.; Rodrigues L.M.A.; Fukushima A.R.; Ricci E.L.; Spinosa H.S.

Fluoxetine alters rat's milk properties causing impact on offspring's development

Tipo

Artigo

Data de publicação

2024

Periódico

Toxicology and Applied Pharmacology

Citações (Scopus)

0

Autores

Abreu G.R.
Zaccarelli-Magalhaes J.
Feba L.S.
Penna E.Y.
Silva J.P.
Teixeira M.V.
Manes M.
Vergara G.A.
Rodrigues L.M.A.
Fukushima A.R.
Ricci E.L.
Spinosa H.S.

Resumo

© 2024 Elsevier Inc.Fluoxetine is an antidepressant used to treat several conditions including postpartum depression. This disease causes cognitive, emotional, behavioral and physical changes, negatively affecting the mother, child and family life. However, fluoxetine is excreted in breast milk, causing short and long-term effects on children who were exposed to the drug during lactation, so studies that seek to uncover the consequences of these effects are needed. Thus, the aim of this study was to evaluate the effects of fluoxetine on the nutritional characteristics of milk and on growth and neurobehavioral development of the offspring on a rat model. Lactating rats were divided into 4 groups: control group and three experimental groups, which were treated with different doses of fluoxetine (1, 10 and 20 mg/kg) during the lactation. Dams body weight and milk properties were measured, as well as offspring's growth and physical and neurobehavioral development. Results showed that the use of fluoxetine during lactation decreased dam's body weight and alters milk's properties, leading to a decrease in offspring's growth until adulthood. Therefore, the use of fluoxetine during lactation needs to be cautiously evaluated, with the benefits to the mothers and the associated risk to the offspring carefully balance.

Assuntos Scopus

Adult , Animals , Antidepressive Agents , Body Weight , Child , Female , Fluoxetine , Humans , Lactation , Milk, Human , Rats