Expressão da Desiodase do Tipo III no cérebro de filhotes de ratas obesas

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dc.contributor.advisorRibeiro, Miriam Oliveirapt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7069953370349465por
dc.contributor.authorTeixeira, Cyntia Moraespt_BR
dc.creator.Latteshttp://lattes.cnpq.br/3689769118736264por
dc.date.accessioned2016-03-15T19:39:56Z
dc.date.accessioned2020-03-19T15:19:57Z
dc.date.available2012-11-30pt_BR
dc.date.available2020-03-19T15:19:57Z
dc.date.issued2012-08-09pt_BR
dc.description.abstractObesity has been considered epidemic in the whole world and is a risk factor for the development of hypertension, dyslipidemia, hyperglycemia, type 2 diabetes and hepatic steatosis. The increase of obesity in during pregnancy not only increases the risk of developing cardiovascular diseases but may also be related to abnormalities in the developing CNS of embryos, for example, reduction of potential long-term (LTP) in the hippocampus and neurogenesis . It is possible that the reduced levels of BDNF observed in these embryos, are involved with the injury in the processes of learning and memory observed in these animals. Studies also show that BDNF is reduced in fetuses of mothers with maternal subclinical hypothyroidism. These puppies have worsening neurological development, with deficits in long and short term memory. Here we evaluated whether maternal obesity may alter levels of BDNF and enzyme expression of type III deiodinase (D3) in the brains of pups, with consequent alteration of local levels of T3 to 7 °, 10 ° and 16 ° day-old post -natal. Our results showed that obesity reduced the expression of D3 on the 7th day of postnatal life of the offspring of obese mothers, but not in later days. There were no significant alterations in the levels of BDNF in any of the evaluated days. Our data suggest that it is possible that thyroid hormone is involved in neurophysiological abnormalities observed in offspring of obese rats.eng
dc.description.sponsorshipUniversidade Presbiteriana Mackenziept_BR
dc.formatapplication/pdfpor
dc.identifier.citationTEIXEIRA, Cyntia Moraes. Expressão da Desiodase do Tipo III no cérebro de filhotes de ratas obesas. 2012. 41 f. Dissertação (Mestrado em Psicologia) - Universidade Presbiteriana Mackenzie, São Paulo, 2012.por
dc.identifier.urihttp://dspace.mackenzie.br/handle/10899/22510
dc.languageporpor
dc.publisherUniversidade Presbiteriana Mackenziepor
dc.rightsAcesso Abertopor
dc.subjectobesidade maternapor
dc.subjectdesiodasepor
dc.subjectobesidade infantilpor
dc.subjectBDNFpor
dc.subjecthipotireoidismopor
dc.subjectmaternal obesityeng
dc.subjectdeiodinaseeng
dc.subjectchildhood obesityeng
dc.subjectBDNFeng
dc.subjecthypothyroidismeng
dc.subject.cnpqCNPQ::CIENCIAS HUMANAS::PSICOLOGIApor
dc.thumbnail.urlhttp://tede.mackenzie.br/jspui/retrieve/3725/Cyntia%20Moraes%20Teixeira.pdf.jpg*
dc.titleExpressão da Desiodase do Tipo III no cérebro de filhotes de ratas obesaspor
dc.typeDissertaçãopor
local.contributor.board1Cysneiros, Roberta Monterazzopt_BR
local.contributor.board1Latteshttp://lattes.cnpq.br/9822955080635086por
local.contributor.board2Scorza, Fúlvio Alexandrept_BR
local.contributor.board2Latteshttp://lattes.cnpq.br/3665794780601169por
local.publisher.countryBRpor
local.publisher.departmentPsicologiapor
local.publisher.initialsUPMpor
local.publisher.programDistúrbios do Desenvolvimentopor
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