Study of the structure-activity relationships of parabens: A practical class Estudo das relações entre estrutura e atividade de parabenos: Uma aula prática

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dc.contributor.authorDos Santos Fernandes J.P.
dc.contributor.authorSavino G.
dc.contributor.authorAmarante A.C.G.
dc.contributor.authorDe Sousa M.R.
dc.contributor.authorDa Silva G.R.
dc.contributor.authorCianciulli M.E.
dc.contributor.authorCorrea M.F.
dc.contributor.authorFerrarini M.
dc.date.accessioned2024-03-13T01:03:43Z
dc.date.available2024-03-13T01:03:43Z
dc.date.issued2013
dc.description.abstractParabens are p-hydroxybenzoic acid esters widely used as preservatives. With the aim of teaching the structure-activity relationships (SAR) knowledge in a practical form, this paper proposed a practical class to view the SAR of parabens as antimicrobial agents. Methyl, ethyl, n-propyl, isopropyl and isopentyl paraben compounds were synthesized and their respective antimicrobial activities were assessed through determination of minimum inhibitory concentrations (MIC) against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 stains. With the MIC values, it was possible to verify theircorrelation with calculated lipophilicity (ClogP). This method can be applied in practical Medicinal Chemistry classes.
dc.description.firstpage890
dc.description.issuenumber6
dc.description.lastpage893
dc.description.volume36
dc.identifier.doi10.1590/S0100-40422013000600026
dc.identifier.issn0100-4042
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36562
dc.relation.ispartofQuimica Nova
dc.rightsAcesso Aberto
dc.subject.otherlanguageDrug synthesis
dc.subject.otherlanguageParabens
dc.subject.otherlanguageSAR
dc.titleStudy of the structure-activity relationships of parabens: A practical class Estudo das relações entre estrutura e atividade de parabenos: Uma aula prática
dc.typeArtigo
local.scopus.citations4
local.scopus.eid2-s2.0-84884767342
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884767342&origin=inward
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