Study of the structure-activity relationships of parabens: A practical class Estudo das relações entre estrutura e atividade de parabenos: Uma aula prática

Dos Santos Fernandes J.P.; Savino G.; Amarante A.C.G.; De Sousa M.R.; Da Silva G.R.; Cianciulli M.E.; Correa M.F.; Ferrarini M.

Study of the structure-activity relationships of parabens: A practical class Estudo das relações entre estrutura e atividade de parabenos: Uma aula prática

Tipo

Artigo

Data de publicação

2013

Periódico

Quimica Nova

Citações (Scopus)

4

Autores

Dos Santos Fernandes J.P.
Savino G.
Amarante A.C.G.
De Sousa M.R.
Da Silva G.R.
Cianciulli M.E.
Correa M.F.
Ferrarini M.

Resumo

Parabens are p-hydroxybenzoic acid esters widely used as preservatives. With the aim of teaching the structure-activity relationships (SAR) knowledge in a practical form, this paper proposed a practical class to view the SAR of parabens as antimicrobial agents. Methyl, ethyl, n-propyl, isopropyl and isopentyl paraben compounds were synthesized and their respective antimicrobial activities were assessed through determination of minimum inhibitory concentrations (MIC) against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 stains. With the MIC values, it was possible to verify theircorrelation with calculated lipophilicity (ClogP). This method can be applied in practical Medicinal Chemistry classes.