Autism, neuroinflammation and animal models for the study of autism: A review Sobre o autismo, neuroinflamação e modelos animais para o estudo de autismo: Uma revisão

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dc.contributor.authorBernardi M.M.
dc.contributor.authorKirsten T.B.
dc.contributor.authorTrindade M.O.
dc.date.accessioned2024-03-13T01:09:10Z
dc.date.available2024-03-13T01:09:10Z
dc.date.issued2012
dc.description.abstractThis article aims to discuss and review the relevance of animal models to study the autistic syndrome. Whereas the animal models may be discussed by its limitation, the contribution to understand the autistic syndrome and the possible procedures, that are not possible in humans for ethical reasons, contributes to reveal some aspects of this disorder. Autism is a developmental neuropsychiatric disorder characterized by several behavioral changes, such as impaired communication and social interaction, repetitive and stereotyped activity and learning difficulties. These symptoms can be severe or moderate and/or partial, but no event is exclusive to autism disorder, which complicates the diagnosis. The neuroanatomical-functional findings and genetic studies are nonspecific. Besides this possible genetic predisposition, environmental factors, such as neuroinflammation, may induce autism. The current studies attributing the immune alterations to mental disorders, including autism relies increasingly on numerous recent publications involving neuroimmune findings and development of various animal models. This article constitutes a review of autism, discussing the animal models to study this syndrome, and the neuroinflammation contribuction in the pathogenesis of autism.
dc.description.firstpage117
dc.description.issuenumber1
dc.description.lastpage127
dc.description.volume20
dc.identifier.doi10.34024/rnc.2012.v20.8304
dc.identifier.issn1984-4905
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36870
dc.relation.ispartofRevista Neurociencias
dc.rightsAcesso Aberto
dc.subject.otherlanguageAnimal behavior
dc.subject.otherlanguageAnimal models
dc.subject.otherlanguageAutism
dc.subject.otherlanguageChild development disorders
dc.titleAutism, neuroinflammation and animal models for the study of autism: A review Sobre o autismo, neuroinflamação e modelos animais para o estudo de autismo: Uma revisão
dc.typeArtigo de revisão
local.scopus.citations5
local.scopus.eid2-s2.0-84862150226
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84862150226&origin=inward
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