Autism, neuroinflammation and animal models for the study of autism: A review Sobre o autismo, neuroinflamação e modelos animais para o estudo de autismo: Uma revisão
Tipo
Artigo de revisão
Data de publicação
2012
Periódico
Revista Neurociencias
Citações (Scopus)
5
Autores
Bernardi M.M.
Kirsten T.B.
Trindade M.O.
Kirsten T.B.
Trindade M.O.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
This article aims to discuss and review the relevance of animal models to study the autistic syndrome. Whereas the animal models may be discussed by its limitation, the contribution to understand the autistic syndrome and the possible procedures, that are not possible in humans for ethical reasons, contributes to reveal some aspects of this disorder. Autism is a developmental neuropsychiatric disorder characterized by several behavioral changes, such as impaired communication and social interaction, repetitive and stereotyped activity and learning difficulties. These symptoms can be severe or moderate and/or partial, but no event is exclusive to autism disorder, which complicates the diagnosis. The neuroanatomical-functional findings and genetic studies are nonspecific. Besides this possible genetic predisposition, environmental factors, such as neuroinflammation, may induce autism. The current studies attributing the immune alterations to mental disorders, including autism relies increasingly on numerous recent publications involving neuroimmune findings and development of various animal models. This article constitutes a review of autism, discussing the animal models to study this syndrome, and the neuroinflammation contribuction in the pathogenesis of autism.