Anti-trypanosomal phenolic derivatives from Baccharis uncinella

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dc.contributor.authorGrecco S.D.S.
dc.contributor.authorFelix M.J.P.
dc.contributor.authorLago J.H.G.
dc.contributor.authorPinto E.G.
dc.contributor.authorTempone A.G.
dc.contributor.authorRomoff P.
dc.contributor.authorFerreira M.J.P.
dc.contributor.authorSartorelli P.
dc.date.accessioned2024-03-13T01:00:51Z
dc.date.available2024-03-13T01:00:51Z
dc.date.issued2014
dc.description.abstractBioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a mixture of three chlorogenic acids (3,4-, 3,5- and 4,5-O-dicaffeoylquinic acids), which displayed in vitro anti-trypanosomal activity. Pectolinaringenin, hispidulin and caffeic acid showed activity against trypomastigotes of Trypanosoma cruzi, exhibiting 50% inhibitory concentration (IC50) values of 52, 81 and 56 mg/mL, respectively, while the chlorogenic acid mixture showed an IC50 value of 61 μg/mL. The flavonoids and cinnamic acid derivatives were evaluated for cytotoxicity against NCTC cells resulting in a 50% cytotoxic concentration (CC50) ranging from 33.82 to 129.1 mg/mL while the chlorogenic acids did not display cytotoxicity (CC50 >150 μg/mL). This is the first report of anti-trypanosomal activity of compounds from B. uncinella.
dc.description.firstpage171
dc.description.issuenumber2
dc.description.lastpage173
dc.description.volume9
dc.identifier.doi10.1177/1934578x1400900210
dc.identifier.issn1555-9475
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36402
dc.relation.ispartofNatural Product Communications
dc.rightsAcesso Aberto
dc.subject.otherlanguageAntitrypanosomal
dc.subject.otherlanguageAsteraceae
dc.subject.otherlanguageBaccharis uncinella
dc.subject.otherlanguageChlorogenic acids
dc.subject.otherlanguageCinnamic acid derivatives
dc.subject.otherlanguageFlavanones
dc.titleAnti-trypanosomal phenolic derivatives from Baccharis uncinella
dc.typeArtigo
local.scopus.citations22
local.scopus.eid2-s2.0-84894500959
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84894500959&origin=inward
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