Anti-trypanosomal phenolic derivatives from Baccharis uncinella
Tipo
Artigo
Data de publicação
2014
Periódico
Natural Product Communications
Citações (Scopus)
22
Autores
Grecco S.D.S.
Felix M.J.P.
Lago J.H.G.
Pinto E.G.
Tempone A.G.
Romoff P.
Ferreira M.J.P.
Sartorelli P.
Felix M.J.P.
Lago J.H.G.
Pinto E.G.
Tempone A.G.
Romoff P.
Ferreira M.J.P.
Sartorelli P.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a mixture of three chlorogenic acids (3,4-, 3,5- and 4,5-O-dicaffeoylquinic acids), which displayed in vitro anti-trypanosomal activity. Pectolinaringenin, hispidulin and caffeic acid showed activity against trypomastigotes of Trypanosoma cruzi, exhibiting 50% inhibitory concentration (IC50) values of 52, 81 and 56 mg/mL, respectively, while the chlorogenic acid mixture showed an IC50 value of 61 μg/mL. The flavonoids and cinnamic acid derivatives were evaluated for cytotoxicity against NCTC cells resulting in a 50% cytotoxic concentration (CC50) ranging from 33.82 to 129.1 mg/mL while the chlorogenic acids did not display cytotoxicity (CC50 >150 μg/mL). This is the first report of anti-trypanosomal activity of compounds from B. uncinella.