Expression of Parkin, APC, APE1, and Bcl-xL in Colorectal Polyps

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dc.contributor.authorKuhl Svoboda Baldin R.
dc.contributor.authorAustralia Paredes Marcondes Ribas C.
dc.contributor.authorde Noronha L.
dc.contributor.authorVeloso da Silva-Camargo C.C.
dc.contributor.authorSantos Sotomaior V.
dc.contributor.authorMartins Sebastiao A.P.
dc.contributor.authorVasconcelos de Castilho A.P.
dc.contributor.authorRodrigues Montemor Netto M.
dc.date.accessioned2024-10-01T06:33:38Z
dc.date.available2024-10-01T06:33:38Z
dc.date.issued2021
dc.description.abstract© The Author(s) 2021.Colorectal cancer can develop through molecular, chromosomal, and epigenetic cumulative changes that transform the normal intestinal epithelium into the colorectal polyps, called conventional adenomas (CAs) or serrated polyps (SPs), recognized as precursors of invasive colorectal neoplasia. These benign lesions need to explore the morphology, histological diagnosis, and biomarkers profile to accurately characterize lesions with potential for evolution to cancer. This study aimed to correlate the immunohistochemical expression of Parkin and Adenomatous Polyposis Coli (APC; tumor suppressors), Human Apurinic/Apyrimidinic endonuclease 1 (APE1), and B-cell lymphoma-extra-large (Bcl-xL; oncogenic proteins) in sporadic colorectal polyps with clinical, endoscopic, and diagnostic data. Immunohistochemical analysis was performed on tissue microarray samples of 306 polyps. Based on the Allred score, the expressions were graduated in the cytoplasm and nucleus of superficial and cryptic cells. There was higher Parkin nuclear expression (p=0.006 and 0.010) and APC cytoplasmic expression in cryptic cells (p<0.001) in SPs. CAs, APE1 (p<0.001) and Bcl-xL (p<0.001) were more expressed in the nuclei and cytoplasms, respectively. These results are related to the biological role proposed for these proteins in cellular functions. They can contribute to the diagnosis criteria for polyps and improve the knowledge of biomarkers that could predict cancer development:
dc.description.firstpage437
dc.description.issuenumber7
dc.description.lastpage449
dc.description.volume69
dc.identifier.doi10.1369/00221554211026296
dc.identifier.issnNone
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/39509
dc.relation.ispartofJournal of Histochemistry and Cytochemistry
dc.rightsAcesso Aberto
dc.subject.otherlanguageAPC
dc.subject.otherlanguageAPE1
dc.subject.otherlanguageBcl-xL
dc.subject.otherlanguagecolorectal cancer
dc.subject.otherlanguageParkin
dc.titleExpression of Parkin, APC, APE1, and Bcl-xL in Colorectal Polyps
dc.typeArtigo
local.scopus.citations1
local.scopus.eid2-s2.0-85107957693
local.scopus.subjectAdenomatous Polyposis Coli Protein
local.scopus.subjectbcl-X Protein
local.scopus.subjectColonic Polyps
local.scopus.subjectDNA-(Apurinic or Apyrimidinic Site) Lyase
local.scopus.subjectGene Expression Regulation
local.scopus.subjectHumans
local.scopus.subjectUbiquitin-Protein Ligases
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85107957693&origin=inward
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