Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae)
Tipo
Artigo
Data de publicação
2010
Periódico
Parasitology Research
Citações (Scopus)
51
Autores
Grecco S.S.
Reimao J.Q.
Tempone A.G.
Sartorelli P.
Romoff P.
Ferreira M.J.P.
Favero O.A.
Lago J.H.G.
Reimao J.Q.
Tempone A.G.
Sartorelli P.
Romoff P.
Ferreira M.J.P.
Favero O.A.
Lago J.H.G.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
In the course of selection of new bioactive compounds from Brazilian flora, the crude MeOH extract from the leaves of Baccharis retusa DC. (Asteraceae) showed potential against Leishmania sp. and Trypanosoma cruzi. Chromatographic fractionation of the dichloromethane phase from MeOH extract yielded great amounts of the bioactive derivative, which was characterized as 5,6,7-trihydroxy-4′-methoxyflavanone. The structure of this compound was established on the basis of spectroscopic data analysis, mainly nuclear magnetic resonance and mass spectrometry. © Springer-Verlag 2010.