Anti-ro antibodies in rheumatoid arthritis
| dc.contributor.author | Zanlorenzi L. | |
| dc.contributor.author | Azevedo P.O. | |
| dc.contributor.author | Silva M.B. | |
| dc.contributor.author | Skare T. | |
| dc.date.accessioned | 2024-03-13T01:08:11Z | |
| dc.date.available | 2024-03-13T01:08:11Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | Background: Some autoantibodies are associated with peculiar clinical findings. Patients with rheumatoid arthritis (RA) may have anti-Ro antibodies. Objective: To study prevalence and clinical associations of anti-Ro antibodies in RA patients. Methods:We studied 385 patients with RA for anti-Ro by Elisa testing and for clinical profile, functional assessment, DAS-28 4v. (ESR), extra-articular manifestations, thyroid function, autoantibodies and treatment. Results: The prevalence of anti-Ro was 8.31%. There was no significant difference in sex distribution, HAQ, DAS-28 or functional classification in patients with po -si tive anti-Ro (p=ns). Patients with anti-Ro were younger at diagnosis (p=0.02). Analyzing extra-articular disorders we found a greater prevalence of cardiac valvular lesions (p<0.001) in patients with anti-Ro antibodies. No differences were found in other extra-articular manifestations, associated hypothyroidism, amyloidosis, treatment requirements, presence of rheumatoid factor (RF) or anti citrullinated protein antibodies (ACPA). Conclusions: We conclude that in RA patients with anti-Ro have disease onset at an earlier age. Anti-Ro may be a risk factor for the development of cardiac valvular lesions. There was no association between this antibody and thyroid disease, amyloidosis and treatment needs. | |
| dc.description.firstpage | 149 | |
| dc.description.issuenumber | 2 | |
| dc.description.lastpage | 152 | |
| dc.description.volume | 37 | |
| dc.identifier.uri | https://dspace.mackenzie.br/handle/10899/36814 | |
| dc.relation.ispartof | Acta Reumatologica Portuguesa | |
| dc.rights | Acesso Restrito | |
| dc.subject.otherlanguage | Anti-ro | |
| dc.subject.otherlanguage | Cardiac valvular lesions | |
| dc.subject.otherlanguage | Rheumatoid arthritis | |
| dc.subject.otherlanguage | Sjogren's syndrome | |
| dc.title | Anti-ro antibodies in rheumatoid arthritis | |
| dc.type | Artigo | |
| local.scopus.citations | 4 | |
| local.scopus.eid | 2-s2.0-84868689062 | |
| local.scopus.updated | 2024-05-01 | |
| local.scopus.url | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84868689062&origin=inward |