Anti-ro antibodies in rheumatoid arthritis
Tipo
Artigo
Data de publicação
2012
Periódico
Acta Reumatologica Portuguesa
Citações (Scopus)
4
Autores
Zanlorenzi L.
Azevedo P.O.
Silva M.B.
Skare T.
Azevedo P.O.
Silva M.B.
Skare T.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
Background: Some autoantibodies are associated with peculiar clinical findings. Patients with rheumatoid arthritis (RA) may have anti-Ro antibodies. Objective: To study prevalence and clinical associations of anti-Ro antibodies in RA patients. Methods:We studied 385 patients with RA for anti-Ro by Elisa testing and for clinical profile, functional assessment, DAS-28 4v. (ESR), extra-articular manifestations, thyroid function, autoantibodies and treatment. Results: The prevalence of anti-Ro was 8.31%. There was no significant difference in sex distribution, HAQ, DAS-28 or functional classification in patients with po -si tive anti-Ro (p=ns). Patients with anti-Ro were younger at diagnosis (p=0.02). Analyzing extra-articular disorders we found a greater prevalence of cardiac valvular lesions (p<0.001) in patients with anti-Ro antibodies. No differences were found in other extra-articular manifestations, associated hypothyroidism, amyloidosis, treatment requirements, presence of rheumatoid factor (RF) or anti citrullinated protein antibodies (ACPA). Conclusions: We conclude that in RA patients with anti-Ro have disease onset at an earlier age. Anti-Ro may be a risk factor for the development of cardiac valvular lesions. There was no association between this antibody and thyroid disease, amyloidosis and treatment needs.