Anti-parietal cell antibodies in patients with autoimmune thyroid diseases

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dc.contributor.authorUtiyama S.R.R.
dc.contributor.authorDe Bem R.S.
dc.contributor.authorSkare T.L.
dc.contributor.authorDe Carvalho G.A.
dc.contributor.authorTeixeira L.M.
dc.contributor.authorBertolazo M.
dc.contributor.authorIoshii S.O.
dc.contributor.authorNisihara R.
dc.date.accessioned2024-03-12T23:58:02Z
dc.date.available2024-03-12T23:58:02Z
dc.date.issued2018
dc.description.abstract© 2017, Italian Society of Endocrinology (SIE).Background: Autoimmune thyroid disease (ATD) patients may have a higher prevalence of anti-parietal cell antibodies (APCA) than normal population. Objective: To study the prevalence of APCA in a cohort of ATD patients to know its association with patient’s clinical profile and gastrointestinal complaints. Methods: APCA was sought for by indirect immunofluorescence test in 243 ATD patients: 136 (55.9%) with Graves’ disease and 107 (44.0%) with Hashimoto’s thyroiditis. A structured questionnaire for gastrointestinal symptoms, previous history of thrombosis, arthralgia and other autoimmune diseases in the patients and their families was applied. Positive and negative APCA individuals were compared. Positive patients were invited to perform upper gastrointestinal endoscopy and biopsy of duodenum segments. Sera from 100 healthy individuals from the same geographic area were used as controls. Results: APCA was present in 20.1% (49/243) of ATD patients: 21.3% (29/136) in the Graves’ sample and 18.6% (20/107) in the Hashimoto’s sample (p = 0.61). Patients with positive APCA had more anemia (p = 0.03; OR = 2.89; 95% CI = 1.03–8.07) and less heartburn (p = 0.01; OR = 0.4; 95% CI = 0.20–0.83). Among the group of 49 APCA-positive patients, 24 agreed with upper endoscopy and it was found that 54.1% had atrophic gastritis. Conclusions: There is a high prevalence of positive APCA in ATD patients. APCA are more common in those with anemia and less common in those with complaints of heartburn. Almost half of positive APCA patients had atrophic gastritis.
dc.description.firstpage523
dc.description.issuenumber5
dc.description.lastpage529
dc.description.volume41
dc.identifier.doi10.1007/s40618-017-0755-2
dc.identifier.issn1720-8386
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35539
dc.relation.ispartofJournal of Endocrinological Investigation
dc.rightsAcesso Restrito
dc.subject.otherlanguageAnti-parietal cells
dc.subject.otherlanguageAutoimmunity
dc.subject.otherlanguageThyroiditis
dc.titleAnti-parietal cell antibodies in patients with autoimmune thyroid diseases
dc.typeArtigo
local.scopus.citations15
local.scopus.eid2-s2.0-85029579962
local.scopus.subjectAdult
local.scopus.subjectAutoantibodies
local.scopus.subjectAutoimmune Diseases
local.scopus.subjectCross-Sectional Studies
local.scopus.subjectFemale
local.scopus.subjectFollow-Up Studies
local.scopus.subjectHashimoto Disease
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectParietal Cells, Gastric
local.scopus.subjectPrognosis
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029579962&origin=inward
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