Anti-parietal cell antibodies in patients with autoimmune thyroid diseases
Tipo
Artigo
Data de publicação
2018
Periódico
Journal of Endocrinological Investigation
Citações (Scopus)
15
Autores
Utiyama S.R.R.
De Bem R.S.
Skare T.L.
De Carvalho G.A.
Teixeira L.M.
Bertolazo M.
Ioshii S.O.
Nisihara R.
De Bem R.S.
Skare T.L.
De Carvalho G.A.
Teixeira L.M.
Bertolazo M.
Ioshii S.O.
Nisihara R.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
© 2017, Italian Society of Endocrinology (SIE).Background: Autoimmune thyroid disease (ATD) patients may have a higher prevalence of anti-parietal cell antibodies (APCA) than normal population. Objective: To study the prevalence of APCA in a cohort of ATD patients to know its association with patient’s clinical profile and gastrointestinal complaints. Methods: APCA was sought for by indirect immunofluorescence test in 243 ATD patients: 136 (55.9%) with Graves’ disease and 107 (44.0%) with Hashimoto’s thyroiditis. A structured questionnaire for gastrointestinal symptoms, previous history of thrombosis, arthralgia and other autoimmune diseases in the patients and their families was applied. Positive and negative APCA individuals were compared. Positive patients were invited to perform upper gastrointestinal endoscopy and biopsy of duodenum segments. Sera from 100 healthy individuals from the same geographic area were used as controls. Results: APCA was present in 20.1% (49/243) of ATD patients: 21.3% (29/136) in the Graves’ sample and 18.6% (20/107) in the Hashimoto’s sample (p = 0.61). Patients with positive APCA had more anemia (p = 0.03; OR = 2.89; 95% CI = 1.03–8.07) and less heartburn (p = 0.01; OR = 0.4; 95% CI = 0.20–0.83). Among the group of 49 APCA-positive patients, 24 agreed with upper endoscopy and it was found that 54.1% had atrophic gastritis. Conclusions: There is a high prevalence of positive APCA in ATD patients. APCA are more common in those with anemia and less common in those with complaints of heartburn. Almost half of positive APCA patients had atrophic gastritis.
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Assuntos Scopus
Adult , Autoantibodies , Autoimmune Diseases , Cross-Sectional Studies , Female , Follow-Up Studies , Hashimoto Disease , Humans , Male , Parietal Cells, Gastric , Prognosis