Therapeutic use of tetrodotoxin in animals Emprego terapêutico da tetrodotoxina em organismos animais
Tipo
Artigo de revisão
Data de publicação
2011
Periódico
Acta Veterinaria Brasilica
Citações (Scopus)
0
Autores
Gomes A.P.
Dos Santos A.
Ambrosio C.E.
Ribeiro M.O.
Dos Santos A.
Ambrosio C.E.
Ribeiro M.O.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
The Tetrodotoxin (TTX) is a powerful neurotoxin produced by bacteria and is found in a fish from Tetraodontidea family, which has been studied since 1884. This toxin has ability to block voltage-dependent sodium channels through guanidine group that binds to the outer opening of the channel. Thanks to this ability tetrodotoxin presents the possibility to be used as a new therapy in several areas. The studies showed that the pharmacological activity of TTX has been extensively studied and its use has been seen in therapy related to chronic pain and neuropathic, the reduction of metastasis in cancer, therapy related diseases in the muscular, skeletal, motor and nervous systems. This toxin has been showing as a promising tool to new treatments.