Therapeutic use of tetrodotoxin in animals Emprego terapêutico da tetrodotoxina em organismos animais
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Artigo de revisão
Date
2011
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Acta Veterinaria Brasilica
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0
Authors
Gomes A.P.
Dos Santos A.
Ambrosio C.E.
Ribeiro M.O.
Dos Santos A.
Ambrosio C.E.
Ribeiro M.O.
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Abstract
The Tetrodotoxin (TTX) is a powerful neurotoxin produced by bacteria and is found in a fish from Tetraodontidea family, which has been studied since 1884. This toxin has ability to block voltage-dependent sodium channels through guanidine group that binds to the outer opening of the channel. Thanks to this ability tetrodotoxin presents the possibility to be used as a new therapy in several areas. The studies showed that the pharmacological activity of TTX has been extensively studied and its use has been seen in therapy related to chronic pain and neuropathic, the reduction of metastasis in cancer, therapy related diseases in the muscular, skeletal, motor and nervous systems. This toxin has been showing as a promising tool to new treatments.