Routes to potentially safer T1 magnetic resonance imaging contrast in a compact plasmonic nanoparticle with enhanced fluorescence
Tipo
Artigo
Data de publicação
2018
Periódico
ACS Nano
Citações (Scopus)
35
Autores
Henderson L.
Neumann O.
Kaffes C.
Zhang R.
Marangoni V.
Ravoori M.K.
Kundra V.
Bankson J.
Nordlander P.
Halas N.J.
Neumann O.
Kaffes C.
Zhang R.
Marangoni V.
Ravoori M.K.
Kundra V.
Bankson J.
Nordlander P.
Halas N.J.
Orientador
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Resumo
© 2018 American Chemical Society.Engineering a compact, near-infrared plasmonic nanostructure with integrated image-enhancing agents for combined imaging and therapy is an important nanomedical challenge. Recently, we showed that Au@SiO2@Au nanomatryoshkas (NM) are a highly promising nanostructure for hosting either T1 MRI or fluorescent contrast agents with a photothermal therapeutic response in a compact geometry. Here, we show that a near-infrared-resonant NM can provide simultaneous contrast enhancement for both T1 magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) by encapsulating both types of contrast agents in the internal silica layer between the Au core and shell. We also show that this method of T1 enhancement is even more effective for Fe(III), a potentially safer contrast agent compared to Gd(III). Fe-NM-based contrast agents are found to have relaxivities 2× greater than those found in the widely used gadolinium chelate, Gd(III) DOTA, providing a practical alternative that would eliminate Gd(III) patient exposure entirely. This dual-modality nanostructure can enable not only tissue visualization with MRI but also fluorescence-based nanoparticle tracking for quantifying nanoparticle distributions in vivo, in addition to a near-infrared photothermal therapeutic response.
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Assuntos Scopus
Enhanced fluorescence , Fluorescence optical imaging , Fluorescent contrast agents , Magnetic Resonance Imaging (MRI) , Nanoparticle tracking , Plasmonic nanoparticle , Plasmonic nanostructures , Simultaneous contrast , Animals , Contrast Media , Fluorescence , Gadolinium , Gold , Iron , Magnetic Resonance Imaging , Manganese , Metal Nanoparticles , Mice , Optical Imaging , Phototherapy , Silicon Dioxide