Oxidized multiwalled carbon nanotubes as antigen delivery system to promote superior CD8+ T Cell response and protection against Cancer

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dc.contributor.authorFaria P.C.B.D.
dc.contributor.authorSantos L.I.D.
dc.contributor.authorCoelho J.P.
dc.contributor.authorRibeiro H.B.
dc.contributor.authorPimenta M.A.
dc.contributor.authorLadeira L.O.
dc.contributor.authorGomes D.A.
dc.contributor.authorFurtado C.A.
dc.contributor.authorGazzinelli R.T.
dc.date.accessioned2024-03-13T01:00:11Z
dc.date.available2024-03-13T01:00:11Z
dc.date.issued2014
dc.description.abstract© 2014 American Chemical Society.Properties like high interfacial area with cellular membranes, unique ability to incorporate multiple functionalization, as well as compatibility and transport in biological fluids make carbon nanotubes (CNTs) useful for a variety of therapeutic and drug-delivery applications. Here we used a totally synthetic hybrid supramolecule as an anticancer vaccine formulation. This complex structure comprises CNTs as delivery system for the Cancer Testis Antigen named NY-ESO-1, allied to a synthetic Toll-Like Receptor agonist. The CNT constructs were rapidly internalized into dendritic cells, both in vitro and in vivo, and served as an intracellular antigen depot. This property favored the induction of strong CD4+ T as well as CD8+ T cell-mediated immune responses against the NY-ESO-1. Importantly, the vaccination significantly delayed the tumor development and prolonged the mice survival, highlighting the potential application of CNTs as a vaccine delivery system to provide superior immunogenicity and strong protection against cancer.
dc.description.firstpage5458
dc.description.issuenumber9
dc.description.lastpage5470
dc.description.volume14
dc.identifier.doi10.1021/nl502911a
dc.identifier.issn1530-6992
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36366
dc.relation.ispartofNano Letters
dc.rightsAcesso Restrito
dc.subject.otherlanguagecancer
dc.subject.otherlanguagecarbon nanotubes
dc.subject.otherlanguageCD8+ activation
dc.subject.otherlanguageNanovaccine
dc.subject.otherlanguageNY-ESO-1
dc.titleOxidized multiwalled carbon nanotubes as antigen delivery system to promote superior CD8+ T Cell response and protection against Cancer
dc.typeArtigo
local.scopus.citations93
local.scopus.eid2-s2.0-84914165932
local.scopus.subjectAntigen delivery system
local.scopus.subjectcancer
local.scopus.subjectCell-mediated immune
local.scopus.subjectMultiple functionalization
local.scopus.subjectNanovaccine
local.scopus.subjectNY-ESO-1
local.scopus.subjectToll-like receptors
local.scopus.subjectVaccine delivery system
local.scopus.subjectAnimals
local.scopus.subjectAnticarcinogenic Agents
local.scopus.subjectAntigens
local.scopus.subjectAntigens, Neoplasm
local.scopus.subjectCalibration
local.scopus.subjectCancer Vaccines
local.scopus.subjectCD4-Positive T-Lymphocytes
local.scopus.subjectCD8-Positive T-Lymphocytes
local.scopus.subjectCell Proliferation
local.scopus.subjectCpG Islands
local.scopus.subjectDendritic Cells
local.scopus.subjectFemale
local.scopus.subjectFlow Cytometry
local.scopus.subjectHumans
local.scopus.subjectLymphocytes
local.scopus.subjectMembrane Proteins
local.scopus.subjectMice
local.scopus.subjectMice, Inbred BALB C
local.scopus.subjectMice, Inbred C57BL
local.scopus.subjectMicroscopy, Electron, Transmission
local.scopus.subjectNanotechnology
local.scopus.subjectNanotubes, Carbon
local.scopus.subjectNeoplasms
local.scopus.subjectOxygen
local.scopus.subjectPeptides
local.scopus.subjectSpectrum Analysis, Raman
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84914165932&origin=inward
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