On lupus, vitamin D and Leukopenia

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dc.contributor.authorSimioni J.A.
dc.contributor.authorHeimovski F.
dc.contributor.authorSkare T.L.
dc.date.accessioned2024-03-13T00:55:16Z
dc.date.available2024-03-13T00:55:16Z
dc.date.issued2016
dc.description.abstract© 2015 Elsevier Editora Ltda.Background: Immune regulation is among the noncalcemic effects of vitamin D. So, thisvitamin may play a role in autoimmune diseases such as systemic lupus erythematosus(SLE).Objectives: To study the prevalence of vitamin D deficiency in SLE and its association withclinical, serological and treatment profile as well as with disease activity. Methods: Serum OH vitamin D3 levels were measured in 153 SLE patients and 85 controls. Data on clinical, serological and treatment profile of lupus patients were obtained throughchart review. Blood cell count and SLEDAI (SLE disease activity index) were measured simul-taneously with vitamin D determination. Results: SLE patients have lower levels of vitamin D than controls (p = 0.03). In univariateanalysis serum vitamin D was associated with leukopenia (p = 0.02), use of cyclophos-phamide (p = 0.007) and methotrexate (p = 0.03). A negative correlation was verified withprednisone dose (p = 0.003). No association was found with disease activity measured bySLEDAI (p = 0.88). In a multiple regression study only leukopenia remained as an independentassociation (B = 4.04; p = 0.02). A negative correlation of serum vitamin level with granulocyte(p = 0.01) was also found, but not with lymphocyte count (p = 0.33).Conclusion: SLE patients have more deficiency of vitamin D than controls. This deficiency isnot associated with disease activity but with leucopenia (granulocytopenia).
dc.description.firstpage206
dc.description.issuenumber3
dc.description.lastpage211
dc.description.volume56
dc.identifier.doi10.1016/j.rbre.2015.08.008
dc.identifier.issn1809-4570
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36089
dc.relation.ispartofRevista Brasileira de Reumatologia
dc.rightsAcesso Aberto
dc.subject.otherlanguageGranulocytopenia
dc.subject.otherlanguageLeukopenia
dc.subject.otherlanguageSystemic lupus erythematosus
dc.subject.otherlanguageVitamin D
dc.titleOn lupus, vitamin D and Leukopenia
dc.typeArtigo
local.scopus.citations5
local.scopus.eid2-s2.0-84982843893
local.scopus.subjectBiomarkers
local.scopus.subjectCase-Control Studies
local.scopus.subjectCross-Sectional Studies
local.scopus.subjectHumans
local.scopus.subjectLeukopenia
local.scopus.subjectLupus Erythematosus, Systemic
local.scopus.subjectVitamin D
local.scopus.subjectVitamin D Deficiency
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84982843893&origin=inward
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