On lupus, vitamin D and Leukopenia

Simioni J.A.; Heimovski F.; Skare T.L.

On lupus, vitamin D and Leukopenia

Tipo

Artigo

Data de publicação

2016

Periódico

Revista Brasileira de Reumatologia

Citações (Scopus)

5

Autores

Simioni J.A.
Heimovski F.
Skare T.L.

Resumo

© 2015 Elsevier Editora Ltda.Background: Immune regulation is among the noncalcemic effects of vitamin D. So, thisvitamin may play a role in autoimmune diseases such as systemic lupus erythematosus(SLE).Objectives: To study the prevalence of vitamin D deficiency in SLE and its association withclinical, serological and treatment profile as well as with disease activity. Methods: Serum OH vitamin D3 levels were measured in 153 SLE patients and 85 controls. Data on clinical, serological and treatment profile of lupus patients were obtained throughchart review. Blood cell count and SLEDAI (SLE disease activity index) were measured simul-taneously with vitamin D determination. Results: SLE patients have lower levels of vitamin D than controls (p = 0.03). In univariateanalysis serum vitamin D was associated with leukopenia (p = 0.02), use of cyclophos-phamide (p = 0.007) and methotrexate (p = 0.03). A negative correlation was verified withprednisone dose (p = 0.003). No association was found with disease activity measured bySLEDAI (p = 0.88). In a multiple regression study only leukopenia remained as an independentassociation (B = 4.04; p = 0.02). A negative correlation of serum vitamin level with granulocyte(p = 0.01) was also found, but not with lymphocyte count (p = 0.33).Conclusion: SLE patients have more deficiency of vitamin D than controls. This deficiency isnot associated with disease activity but with leucopenia (granulocytopenia).

Assuntos Scopus

Biomarkers , Case-Control Studies , Cross-Sectional Studies , Humans , Leukopenia , Lupus Erythematosus, Systemic , Vitamin D , Vitamin D Deficiency