Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa

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dc.contributor.authorCouto E.V.
dc.contributor.authorBallin C.R.
dc.contributor.authorSampaio C.P.P.
dc.contributor.authorMaeda C.A.S.
dc.contributor.authorBallin C.H.
dc.contributor.authorDassi C.S.
dc.contributor.authorMiura L.Y.
dc.date.accessioned2024-03-13T00:55:36Z
dc.date.available2024-03-13T00:55:36Z
dc.date.issued2016
dc.description.abstract© 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.Introduction: Bismuth subgallate is a salt derived from heavy metal. The aim of this study was to evaluate the effect of this salt on some phases of healing. Objectives: To assess the effect of subgallate on mucosa and to evaluate the association between the use of bismuth subgallate and neogenesis of vessels in oral mucosal wounds. Methods: This was a prospective and experimental study. This study used sixty rats, which were divided into control and experimental groups. The animals were submitted to a surgical procedure, which caused oral mucosal injury. A saline solution was applied on the wound of the control group, and in the experimental group, a solution of bismuth subgallate was administrated. Results: The experimental group showed greater inflammatory reaction with increasing monomorphic proliferation. There was increased vessel proliferation in the control group. Conclusion: Bismuth subgallate had a negative influence on the healing process, delaying the rate of new vessel formation and optimal wound healing.
dc.description.firstpage17
dc.description.issuenumber1
dc.description.lastpage25
dc.description.volume82
dc.identifier.doi10.1016/j.bjorl.2014.12.009
dc.identifier.issn1808-8686
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36108
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.rightsAcesso Aberto
dc.subject.otherlanguageAngiogenesis-inducing agents
dc.subject.otherlanguageTonsillectomy
dc.subject.otherlanguageWound healing
dc.titleExperimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa
dc.typeArtigo
local.scopus.citations3
local.scopus.eid2-s2.0-84958722041
local.scopus.subjectAngiogenesis Inducing Agents
local.scopus.subjectAnimals
local.scopus.subjectDisease Models, Animal
local.scopus.subjectGallic Acid
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMouth Mucosa
local.scopus.subjectOrganometallic Compounds
local.scopus.subjectProspective Studies
local.scopus.subjectRats
local.scopus.subjectTonsillectomy
local.scopus.subjectWound Healing
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84958722041&origin=inward
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