Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa
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Artigo
Date
2016
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Brazilian Journal of Otorhinolaryngology
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3
Authors
Couto E.V.
Ballin C.R.
Sampaio C.P.P.
Maeda C.A.S.
Ballin C.H.
Dassi C.S.
Miura L.Y.
Ballin C.R.
Sampaio C.P.P.
Maeda C.A.S.
Ballin C.H.
Dassi C.S.
Miura L.Y.
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Abstract
© 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.Introduction: Bismuth subgallate is a salt derived from heavy metal. The aim of this study was to evaluate the effect of this salt on some phases of healing. Objectives: To assess the effect of subgallate on mucosa and to evaluate the association between the use of bismuth subgallate and neogenesis of vessels in oral mucosal wounds. Methods: This was a prospective and experimental study. This study used sixty rats, which were divided into control and experimental groups. The animals were submitted to a surgical procedure, which caused oral mucosal injury. A saline solution was applied on the wound of the control group, and in the experimental group, a solution of bismuth subgallate was administrated. Results: The experimental group showed greater inflammatory reaction with increasing monomorphic proliferation. There was increased vessel proliferation in the control group. Conclusion: Bismuth subgallate had a negative influence on the healing process, delaying the rate of new vessel formation and optimal wound healing.
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Keywords
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Angiogenesis Inducing Agents , Animals , Disease Models, Animal , Gallic Acid , Humans , Male , Mouth Mucosa , Organometallic Compounds , Prospective Studies , Rats , Tonsillectomy , Wound Healing