Temperature effects on a whole metabolic reaction cannot be inferred from its components

Página do item simplificado
dc.contributor.authorChaui-Berlinck J.G.
dc.contributor.authorNavas C.A.
dc.contributor.authorAlves Monteiro L.H.
dc.contributor.authorPereira Wilken Bicudo J.E.
dc.date.accessioned2024-03-13T01:44:59Z
dc.date.available2024-03-13T01:44:59Z
dc.date.issued2004
dc.description.abstractChanges in temperature affect the kinetic energy of the constituents of a system at the molecular level and have pervasive effects on the physiology of the whole organism. A mechanistic link between these levels of organization has been assumed and made explicit through the use of values of organismal Q 10 to infer control of metabolic rate. To be valid this postulate requires linearity and independence of the isolated reaction steps, assumptions not accepted by all. We address this controversy by applying dynamic systems theory and metabolic control analysis to a metabolic pathway model. It is shown that temperature effects on isolated steps cannot rigorously be extrapolated to higher levels of organization.
dc.description.firstpage1415
dc.description.issuenumber1546
dc.description.lastpage1419
dc.description.volume271
dc.identifier.doi10.1098/rspb.2004.2727
dc.identifier.issn1471-2970
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37928
dc.relation.ispartofProceedings of the Royal Society B: Biological Sciences
dc.rightsAcesso Restrito
dc.subject.otherlanguageDynamic systems
dc.subject.otherlanguageFlux control theory
dc.subject.otherlanguageMetabolic rate
dc.subject.otherlanguageTemperature effects
dc.titleTemperature effects on a whole metabolic reaction cannot be inferred from its components
dc.typeArtigo
local.scopus.citations19
local.scopus.eid2-s2.0-3042849241
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=3042849241&origin=inward
Arquivos
Coleções
Artigos de periódico