Temperature effects on a whole metabolic reaction cannot be inferred from its components
Tipo
Artigo
Data de publicação
2004
Periódico
Proceedings of the Royal Society B: Biological Sciences
Citações (Scopus)
19
Autores
Chaui-Berlinck J.G.
Navas C.A.
Alves Monteiro L.H.
Pereira Wilken Bicudo J.E.
Navas C.A.
Alves Monteiro L.H.
Pereira Wilken Bicudo J.E.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
Changes in temperature affect the kinetic energy of the constituents of a system at the molecular level and have pervasive effects on the physiology of the whole organism. A mechanistic link between these levels of organization has been assumed and made explicit through the use of values of organismal Q 10 to infer control of metabolic rate. To be valid this postulate requires linearity and independence of the isolated reaction steps, assumptions not accepted by all. We address this controversy by applying dynamic systems theory and metabolic control analysis to a metabolic pathway model. It is shown that temperature effects on isolated steps cannot rigorously be extrapolated to higher levels of organization.