Mucocutaneous involvement in systemic lupus erythematosus and its association with autoantibodies Envolvimento mucocutâneo no lúpus eritematoso sistêmico e sua associação com auto-anticorpos

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dc.contributor.authorMachado A.P.B.
dc.contributor.authorDykyj M.T.
dc.contributor.authorVandresen N.
dc.contributor.authorSkare T.L.
dc.date.accessioned2024-03-13T01:37:25Z
dc.date.available2024-03-13T01:37:25Z
dc.date.issued2008
dc.description.abstractBACKGROUND - Mucocutaneous manifestations are very common in systemic lupus erythematosus and vary widely. OBJECTIVES - To study the prevalence of mucocutaneous lesions in systemic lupus erythematosus and to verify their possible association with autoantibodies. METHODS - One hundred and thirteen patients with systemic lupus erythematosus underwent clinical history directed to skin disorders and ectoscopic examination. Their charts were reviewed for demographic data and autoantibody profile (anti-Ro/SS-A, anti-La/SS-B, anti-DNA and anti-Sm). RESULTS - The most prevalent findings were photosensitivity (83.1%), alopecia (65.4%), butterfly rash (54.3%) and Raynaud's phenomenon (53.9%). In 46.9% of patients there was mucocutaneous complaint upon diagnosis. We found an association between subacute cutaneous lupus and anti-Ro/SS-A (p=0.03), Raynaud's phenomenon and anti-Sm (p=0.05), butterfly rash and anti-DNA (p=0.03). CONCLUSION - Mucocutaneous lesions are present in most systemic lupus patients and in almost half of them they are present at diagnosis. The most common findings were photosensitivity, alopecia, butterfly rash and Raynaud's phenomenon. ©2008 by Anais Brasileiros de Dermatologia.
dc.description.firstpage323
dc.description.issuenumber4
dc.description.lastpage328
dc.description.volume83
dc.identifier.doi10.1590/S0365-05962008000400006
dc.identifier.issn0365-0596
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37513
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsAcesso Aberto
dc.subject.otherlanguageAntibodies, antinuclear
dc.subject.otherlanguageLupus erythematosus, cutaneous
dc.subject.otherlanguageLupus erythematosus, systemic
dc.subject.otherlanguageMucous membrane
dc.subject.otherlanguageSkin diseases
dc.titleMucocutaneous involvement in systemic lupus erythematosus and its association with autoantibodies Envolvimento mucocutâneo no lúpus eritematoso sistêmico e sua associação com auto-anticorpos
dc.typeArtigo
local.scopus.citations3
local.scopus.eid2-s2.0-55249118385
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=55249118385&origin=inward
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