Mucocutaneous involvement in systemic lupus erythematosus and its association with autoantibodies Envolvimento mucocutâneo no lúpus eritematoso sistêmico e sua associação com auto-anticorpos
Tipo
Artigo
Data de publicação
2008
Periódico
Anais Brasileiros de Dermatologia
Citações (Scopus)
3
Autores
Machado A.P.B.
Dykyj M.T.
Vandresen N.
Skare T.L.
Dykyj M.T.
Vandresen N.
Skare T.L.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
BACKGROUND - Mucocutaneous manifestations are very common in systemic lupus erythematosus and vary widely. OBJECTIVES - To study the prevalence of mucocutaneous lesions in systemic lupus erythematosus and to verify their possible association with autoantibodies. METHODS - One hundred and thirteen patients with systemic lupus erythematosus underwent clinical history directed to skin disorders and ectoscopic examination. Their charts were reviewed for demographic data and autoantibody profile (anti-Ro/SS-A, anti-La/SS-B, anti-DNA and anti-Sm). RESULTS - The most prevalent findings were photosensitivity (83.1%), alopecia (65.4%), butterfly rash (54.3%) and Raynaud's phenomenon (53.9%). In 46.9% of patients there was mucocutaneous complaint upon diagnosis. We found an association between subacute cutaneous lupus and anti-Ro/SS-A (p=0.03), Raynaud's phenomenon and anti-Sm (p=0.05), butterfly rash and anti-DNA (p=0.03). CONCLUSION - Mucocutaneous lesions are present in most systemic lupus patients and in almost half of them they are present at diagnosis. The most common findings were photosensitivity, alopecia, butterfly rash and Raynaud's phenomenon. ©2008 by Anais Brasileiros de Dermatologia.