A betabaculovirus-encoded gp64 homolog codes for a functional envelope fusion protein
Tipo
Artigo
Data de publicação
2016
Periódico
Journal of Virology
Citações (Scopus)
12
Autores
Ardisson-Araujo D.M.P.
Melo F.L.
Clem R.J.
Wolff J.L.C.
Ribeiro B.M.
Melo F.L.
Clem R.J.
Wolff J.L.C.
Ribeiro B.M.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
© 2016, American Society for Microbiology.The GP64 envelope fusion protein is a hallmark of group I alphabaculoviruses. However, the Diatraea saccharalis granulovirus genome sequence revealed the first betabaculovirus species harboring a gp64 homolog (disa118). In this work, we have shown that this homolog encodes a functional envelope fusion protein and could enable the infection and fusogenic abilities of a gp64-null prototype baculovirus. Therefore, GP64 may complement or may be in the process of replacing F protein activity in this virus lineage.
Descrição
Palavras-chave
Assuntos Scopus
Animals , Genetic Complementation Test , Granulovirus , Lepidoptera , Viral Fusion Proteins , Virus Internalization