Resistance exercise and testosterone treatment alters the proportion of numerical density of capillaries of the left ventricle of aging Wistar rats

Goncalves L.; De Souza R.R.; Maifrino L.B.M.; Caperuto E.C.; Carbone P.O.; Rodrigues B.; Gama E.F.

Resistance exercise and testosterone treatment alters the proportion of numerical density of capillaries of the left ventricle of aging Wistar rats

Tipo

Artigo

Data de publicação

2014

Periódico

Aging Male

Citações (Scopus)

13

Autores

Goncalves L.
De Souza R.R.
Maifrino L.B.M.
Caperuto E.C.
Carbone P.O.
Rodrigues B.
Gama E.F.

Resumo

© 2014 Informa UK Ltd.Changes in the heart compartments that leads to pathological cardiac hypertrophy can be related to testosterone reduction in aging males since heart cells are susceptible to androgens. Resistance exercise delays the changes of aging.Aim: This study aimed to analyze alterations of the left ventricle of aged rats subjected to resistance exercise with administration of testosterone.Methods: Wistar rats were divided into five groups: C Group (control), S Group (sedentary), ST Group (sedentary treated with testosterone), T Group (trained) and TT Group (trained and treated with testosterone), strength training protocol and testosterone treatment were 16 weeks long. All groups were sacrificed at 16 months except for C group, sacrificed at 13 months.Results: There was no change in the weight of the heart or the left ventricle between the groups. ST group showed increase in Nv [cap] density of capillaries and collagen, with no differences in interstitial space. Both trained groups (T and TT) showed increase in the numerical density of capillaries (Nv [cap]) and in the interstitial space, with no changes in collagen.Conclusion: Resistance exercise combined with testosterone triggered a response of compensatory adjustment in the increase of Nv [cap], collagen and interstitial space, increasing perfusion and nutrition to the heart.

Assuntos Scopus

Animals , Capillaries , Heart Ventricles , Male , Physical Conditioning, Animal , Rats, Wistar , Resistance Training , Testosterone , Ventricular Function, Left